Small-caliber vascular grafts based on a piezoelectric nanocomposite elastomer: Mechanical properties and biocompatibility

The development of small-caliber grafts still represents a challenge in the field of vascular prostheses. Among other factors, the mechanical properties mismatch between natural vessels and artificial devices limits the efficacy of state-of-the-art materials. In this paper, a novel nanocomposite graft with an internal diameter of 6 nun is proposed. The device is obtained through spray deposition using a semi-interpenetrating polymeric network combining poly(ether)urethane and polydimethilsyloxane. The inclusion of BaTiO3 nanoparticles endows the scaffold with piezoelectric properties, which may be exploited in the future to trigger beneficial biological effects. Graft characterization demonstrated a good nanoparticle dispersion and an overall porosity that was not influenced by the presence of nanoparticles. Graft mechanical properties resembled (or even ameliorated) the ones of natural vessels: both doped and non-doped samples showed a Young's modulus of similar to 700 kPa in the radial direction and similar to 900 kPa in the longitudinal direction, an ultimate tensile strength of similar to 1 MPa, a strain to failure of similar to 700%, a suture retention force of similar to 1.7 N and a flexural rigidity of similar to 2.5 x 10(-5) N m(2). The two grafts differed in terms of burst strength that resulted similar to 800 kPa for the control non-doped samples and similar to 1100 kPa for the doped ones. The graft doped with BaTiO3 nanoparticles showed a d(33) coefficient of 1.91 pm/V, almost double than the non-doped control. The device resulted highly stable, with a mass loss smaller than 2% over 3 months and an excellent biocompatibility.