Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial dysfunction might represent a crucial element in the onset and progression of CHF and, as such, a promising therapeutic target.
Targeting Mitochondrial Dysfunction in Chronic Heart Failure: Current Evidence and Potential Approaches
AIMO, ALBERTO;BORRELLI, CHIARA;VERGARO, Giuseppe;MIRIZZI, GIANLUCA;VALLEGGI, ALESSANDRO;PASSINO, Claudio;EMDIN, MICHELE;Giannoni, Alberto
2016-01-01
Abstract
Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial dysfunction might represent a crucial element in the onset and progression of CHF and, as such, a promising therapeutic target.File in questo prodotto:
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